STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E02H1.5Uncharacterized protein E02H1.5. (253 aa)    
Predicted Functional Partners:
tag-322
Uncharacterized protein.
   
 0.951
rtcb-1
RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs. Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress- induced unfolded protein response. Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1. Belongs to the RtcB family.
   
 0.949
tofu-2
B30.2/SPRY domain-containing protein.
   
 
 0.893
Y55F3BR.1
Uncharacterized protein.
   
 
 0.890
arch-1
Protein archease-like; Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (F16A11.2).
   
 
 0.629
M142.5
AD domain-containing protein.
   
 
 0.619
T04F8.6
Uncharacterized protein.
    
 
 0.570
R11H6.5
Uncharacterized protein.
   
 
 0.515
ddx-15
Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.
   
  
 0.512
smu-1
Smu-1 suppressor of mec-8 and unc-52 protein; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site. In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18.
   
  
 0.444
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.