STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zmp-1Matrix metalloproteinase-A; Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium. (521 aa)    
Predicted Functional Partners:
him-4
EGF-like domain-containing protein.
      
 0.894
fos-1
Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily.
   
 
 0.892
cdh-3
Cadherin-3; Cell adhesion protein involved in the control of epithelial morphogenesis. Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development.
   
  
 0.890
egl-43
Uncharacterized protein.
      
 0.850
nhr-67
Nuclear hormone receptor family member nhr-67; Orphan nuclear receptor. In males, plays an essential role in the migration of the linker cell which guides gonad elongation during the L3 and L4 stages of larval development by negatively regulating the expression of netrin receptor unc-5 at the mid-L3 stage.
    
 
 0.815
ina-1
Integrin alpha ina-1; Plays a role in cell migration, axon fasciculation, and morphogenesis. During gonad morphogenesis, involved in distal tip cells (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p. Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis. Belongs to the integrin alpha chain family.
    
 
 0.770
egl-17
EGL-17; Belongs to the heparin-binding growth factors family.
      
 0.763
pat-3
Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...]
    
 
 0.711
unc-40
Unc-40 protein.
   
  
 0.701
dhs-31
DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.700
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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