STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F01D4.5PHD-type domain-containing protein. (223 aa)    
Predicted Functional Partners:
bgnt-1.1
B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog.
      
 0.917
C34D4.2
Serine/threonine-protein phosphatase.
    
 
 0.888
srh-281
Serpentine Receptor, class H.
      
 0.853
oac-15
Acyl_transf_3 domain-containing protein.
      
 0.853
tatn-1
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
      
 0.810
rap-3
RAP homolog (Vertebrate Rap GTPase family).
    
 
 0.698
ash-2
Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...]
   
 
 0.695
lgc-45
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
      
 0.692
mtm-5
Myotubularin-related protein 5; Probably acts as an adapter for other myotubularin-like phosphatases (Probable); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.
   
 
 0.661
lin-49
Protein lin-49; Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.
   
 
 0.656
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.