STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sur-7SUppressor of activated let-60 Ras. (371 aa)    
Predicted Functional Partners:
cdf-1
Cation diffusion facilitator family protein 1; Involved in the regulation of Pn.p cell fate determination. Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling. Involved in zinc transport from the intestinal lumen to the pseudocoelum.
   
  
 0.924
cdf-2
Cation Diffusion Facilitator family.
      
 0.850
haly-1
Histidine ammonia-lyase; Belongs to the PAL/histidase family.
      
 0.810
ttm-1
Zinc transporter ttm-1; Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc. Involved in cadmium resistance, possibly by promoting its transport from cells. Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway.
      
 0.801
natc-1
N-alpha-AcetylTransferase C complex subunit.
   
  
 0.700
C30G12.6
Uncharacterized protein C30G12.6.
      
 0.669
hmg-20
HMG box domain-containing protein.
      
 0.669
zipt-15
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
      
 0.668
sulp-1
STAS domain-containing protein.
      
 0.660
ogr-2
SPK domain-containing protein.
      
 0.660
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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