STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
npp-5Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import. (813 aa)    
Predicted Functional Partners:
npp-23
Nuclear Pore complex Protein.
   
 0.999
npp-15
Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family.
   
 0.999
npp-11
Nuclear Pore complex Protein.
   
 0.999
npp-6
Nuclear Pore complex Protein.
   
 0.999
npp-2
Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).
   
 0.999
npp-18
Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus.
   
 0.999
npp-3
Nuclear Pore complex Protein.
   
 0.998
npp-20
Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family.
   
 0.998
npp-14
Nuclear pore complex protein 14; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4.
   
 0.997
npp-13
Nuclear pore protein.
   
 0.997
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.