STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F07A11.4Ubiquitin carboxyl-terminal hydrolase. (1095 aa)    
Predicted Functional Partners:
hif-1
Hypoxia-inducible factor 1; A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureu [...]
   
 0.909
otub-3
OTU domain-containing protein.
      
 0.770
cyld-1
USP domain-containing protein.
      
 0.745
plr-1
Probable E3 ubiquitin-protein ligase plr-1; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non- canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG. Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the [...]
   
 
 0.724
F54D1.6
Uncharacterized protein F54D1.6.
   
  
 0.722
C46C2.2
MFS domain-containing protein.
   
  
 0.713
oac-29
Acyl_transf_3 domain-containing protein.
    
 
 0.703
nspd-3
Nematode Specific Peptide family, group D.
      
 0.691
oac-30
Acyl_transf_3 domain-containing protein.
   
 
 0.677
ugt-19
UDP-GlucuronosylTransferase.
   
  
 0.671
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.