Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| daf-12 | daf-36 | F11A1.3a.1 | C12D8.5.1 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 0.911 |
| daf-12 | daf-9 | F11A1.3a.1 | T13C5.1a.1 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 0.980 |
| daf-12 | dhs-16 | F11A1.3a.1 | C10F3.2.1 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | 3 beta-hydroxysteroid dehydrogenase dhs-16; 3 beta-hydroxysteroid dehydrogenase that converts 3 beta- hydroxysteroids to 3-ketosteroids, an essential step in the production of Delta(7)-dafachronic acid from cholesterol. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. Required for longevity in the absence of the germline. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.814 |
| daf-12 | din-1 | F11A1.3a.1 | F07A11.6b.1 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | Daf-12-interacting protein 1; [Isoform d]: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause. | 0.964 |
| daf-12 | gei-8 | F11A1.3a.1 | C14B9.6a.3 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | 0.620 |
| daf-12 | hsd-1 | F11A1.3a.1 | Y6B3B.11.1 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | 3Beta_HSD domain-containing protein. | 0.700 |
| daf-12 | nhr-48 | F11A1.3a.1 | ZK662.3b.2 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | Nuclear hormone receptor family member nhr-48; Orphan nuclear receptor. | 0.409 |
| daf-12 | strm-1 | F11A1.3a.1 | H14E04.1.1 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | Sterol 4-C-methyltransferase strm-1; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of cholesterol and other sterols. May irreversibly shunt sterols away from dafachronic acid production. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 0.748 |
| daf-36 | daf-12 | C12D8.5.1 | F11A1.3a.1 | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | 0.911 |
| daf-36 | daf-9 | C12D8.5.1 | T13C5.1a.1 | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 0.954 |
| daf-36 | dhs-16 | C12D8.5.1 | C10F3.2.1 | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 3 beta-hydroxysteroid dehydrogenase dhs-16; 3 beta-hydroxysteroid dehydrogenase that converts 3 beta- hydroxysteroids to 3-ketosteroids, an essential step in the production of Delta(7)-dafachronic acid from cholesterol. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. Required for longevity in the absence of the germline. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.930 |
| daf-36 | din-1 | C12D8.5.1 | F07A11.6b.1 | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | Daf-12-interacting protein 1; [Isoform d]: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause. | 0.745 |
| daf-36 | hsd-1 | C12D8.5.1 | Y6B3B.11.1 | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 3Beta_HSD domain-containing protein. | 0.915 |
| daf-36 | strm-1 | C12D8.5.1 | H14E04.1.1 | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | Sterol 4-C-methyltransferase strm-1; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of cholesterol and other sterols. May irreversibly shunt sterols away from dafachronic acid production. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 0.814 |
| daf-9 | daf-12 | T13C5.1a.1 | F11A1.3a.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] | 0.980 |
| daf-9 | daf-36 | T13C5.1a.1 | C12D8.5.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 0.954 |
| daf-9 | dhs-16 | T13C5.1a.1 | C10F3.2.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 3 beta-hydroxysteroid dehydrogenase dhs-16; 3 beta-hydroxysteroid dehydrogenase that converts 3 beta- hydroxysteroids to 3-ketosteroids, an essential step in the production of Delta(7)-dafachronic acid from cholesterol. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. Required for longevity in the absence of the germline. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.865 |
| daf-9 | din-1 | T13C5.1a.1 | F07A11.6b.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Daf-12-interacting protein 1; [Isoform d]: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause. | 0.853 |
| daf-9 | hsd-1 | T13C5.1a.1 | Y6B3B.11.1 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | 3Beta_HSD domain-containing protein. | 0.905 |
| daf-9 | nhr-48 | T13C5.1a.1 | ZK662.3b.2 | Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...] | Nuclear hormone receptor family member nhr-48; Orphan nuclear receptor. | 0.419 |
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