STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lgc-36Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (536 aa)    
Predicted Functional Partners:
lgc-37
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
 
0.855
gab-1
Gamma-aminobutyric acid receptor subunit beta; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
  
0.847
lgg-1
Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...]
    
 
 0.713
exp-1
Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells.
  
 
0.709
lgc-35
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
 
0.706
B0034.5
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.699
C06A1.3
Putative serine/threonine-protein phosphatase C06A1.3.
    
 
 0.699
dhs-17
DeHydrogenases, Short chain.
      
 0.699
F14H8.2
Uncharacterized protein.
   
  
 0.698
lgc-38
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
 
0.695
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.