STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F08A8.5Galactoside 2-alpha-L-fucosyltransferase; Selectively catalyzes the addition of fucose in alpha 1-2 linkage to Gal-beta-(1->3)-GalNAc-alpha-R, Gal-beta-(1->3)-(GlcNAc- beta-(1->6))-GalNAc-alpha-R and Gal-beta-(1->3)-GalNAc acceptors but not Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta-(1->4)-Glc in vitro. (402 aa)    
Predicted Functional Partners:
bre-1
GDP-mannose 4,6 dehydratase 1; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. Involved in susceptibility to pore- forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds. Has a role in determining brood size. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
  
  
 0.817
galt-1
Beta-1,4-galactosyltransferase galt-1; Catalyzes the transfer of beta-galactose from UDP-galactose to position 4 of alpha-1,6-linked fucose at the reducing end GlcNAc in N-glycan cores. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds.
      
 0.805
bre-2
Beta-1,3-galactosyltransferase bre-2; Transfers N-acetylgalactosamine onto carbohydrate substrates (By similarity). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.
      
 0.803
lec-10
Galectin.
      
 0.759
fut-8
Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds.
      
 0.754
bre-3
Beta-1,4-mannosyltransferase bre-3; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre- 1, bre-2, bre-4 and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. Has a role in determining brood size.
     
 0.704
bre-5
Beta-1,3-galactosyltransferase bre-5; Transfers N-acetylgalactosamine onto mannose groups of carbohydrate substrates. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3, and bre-4. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.
      
 0.700
bre-4
Beta-1,4-N-acetylgalactosaminyltransferase bre-4; Catalyzes the transfer of galactose onto proteins or lipids. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3 and bre-5. Belongs to the glycosyltransferase 7 family.
      
 0.700
lec-6
Galectin.
      
 0.696
fut-1
Alpha-(1,3)-fucosyltransferase fut-1; Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the first GlcNAc residue (with or without alpha 1,6-linked fucose), next to the peptide chains in N-glycans. Unlike in mammals, does not require the prior action of N-acetylglucosaminyltransferase I to generate complex N-glycans.
      
 0.691
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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