STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
erd-2ER lumen protein-retaining receptor erd-2.1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family. (213 aa)    
Predicted Functional Partners:
C27A7.6
Uncharacterized protein.
      
 0.910
marc-4
RING-CH-type domain-containing protein.
      
 0.910
sec-12
WD_REPEATS_REGION domain-containing protein.
   
 
 0.771
uso-1
USO1 (Yeast transport protein) homolog.
     
 0.760
ykt-6
YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family.
   
 
 0.747
dnj-7
DNaJ domain (Prokaryotic heat shock protein).
   
 
 0.745
copb-1
Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
   
 0.733
F47G9.1
GOLD domain-containing protein.
   
 0.717
nsf-1
Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family.
   
 
 0.710
acl-8
PlsC domain-containing protein.
    
 
 0.710
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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