STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
msh-5MutS protein homolog 5; Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks. (1369 aa)    
Predicted Functional Partners:
him-14
MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair.
  
 
0.999
mlh-1
DNA_mis_repair domain-containing protein.
 
 
 0.988
spo-11
Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.
   
 
 0.968
rad-51
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA.
  
 
 0.954
pms-2
PMS (Post Meiotic Segregation) family.
 
 
 0.945
cosa-1
CrossOver Site Associated.
   
 
 0.944
mus-81
ERCC4 domain-containing protein.
   
 
 0.931
zhp-3
RING-type domain-containing protein.
   
 
 0.931
rmh-1
DUF1767 domain-containing protein.
   
  
 0.886
syp-2
Uncharacterized protein.
   
  
 0.860
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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