STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
molo-1Uncharacterized protein. (298 aa)    
Predicted Functional Partners:
lhfp-4
Lipoma Hmgic (HMGIC) Fusion Partner-like homolog.
      
 0.852
unc-50
Protein unc-50; Required for cell surface expression of acetylcholine receptors in body-wall muscles.
      
 0.760
oig-4
Immunoglobulin domain-containing protein oig-4; Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation.
      
 0.758
eat-18
Uncharacterized protein.
      
 0.741
lev-10
LEV-10A protein.
   
  
 0.706
ric-3
Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family.
   
  
 0.704
lev-9
Protein lev-9; Scaffolding protein that is necessary to cluster acetylcholine receptors at neuromuscular junctions.
      
 0.698
acr-8
Acetylcholine receptor 8.
   
  
 0.650
lev-8
Uncharacterized protein.
      
 0.631
eat-2
Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...]
   
 
 0.627
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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