STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kup-1Protein kup-1. (385 aa)    
Predicted Functional Partners:
Y56A3A.7
Uncharacterized protein.
      
 0.891
T07D1.2
Zf-RING_UBOX domain-containing protein.
      
 0.850
hel-1
Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly.
   
 
 0.833
ppfr-1
Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.
   
  
 0.767
F33D11.10
Uncharacterized protein; Belongs to the DEAD box helicase family.
   
 
 0.738
Y53G8AR.6
SAP domain-containing protein.
   
 
 0.709
thoc-2
THO Complex (Transcription factor/nuclear export) subunit.
   
 
 0.687
B0495.8
Uncharacterized protein B0495.8; Belongs to the Luc7 family.
   
  
 0.686
mag-1
Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family.
   
 
 0.626
chaf-1
CHromatin Assembly Factor.
   
  
 0.611
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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