node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ZK430.5 | evl-14 | ZK430.5.1 | H38K22.1.1 | Peptidase C50 domain-containing protein. | Uncharacterized protein. | 0.477 |
ZK430.5 | him-1 | ZK430.5.1 | F28B3.7a.1 | Peptidase C50 domain-containing protein. | Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair (By similarity). Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). | 0.423 |
ZK430.5 | pqn-85 | ZK430.5.1 | Y43H11AL.3a.1 | Peptidase C50 domain-containing protein. | Nipped-B-like protein pqn-85; Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). | 0.567 |
ZK430.5 | rec-8 | ZK430.5.1 | W02A2.6a.1 | Peptidase C50 domain-containing protein. | Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent. | 0.811 |
ZK430.5 | scc-1 | ZK430.5.1 | F10G7.4.1 | Peptidase C50 domain-containing protein. | Sister chromatid cohesion protein 1; Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). | 0.858 |
ZK430.5 | scc-3 | ZK430.5.1 | F18E2.3.1 | Peptidase C50 domain-containing protein. | Cohesin subunit scc-3; Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Has a role in stabilization of homologous chromosome associations during meiotic syn [...] | 0.904 |
ZK430.5 | smc-3 | ZK430.5.1 | Y47D3A.26b.1 | Peptidase C50 domain-containing protein. | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] | 0.984 |
ZK430.5 | smc-5 | ZK430.5.1 | C27A2.1.1 | Peptidase C50 domain-containing protein. | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | 0.766 |
ZK430.5 | smcl-1 | ZK430.5.1 | C44C10.4.1 | Peptidase C50 domain-containing protein. | Structural maintenance of chromosomes-like protein 1; Acts as a modulator of condensin function, possibly by binding to the condensin SMC subunits and thereby inhibiting their function. Negatively regulates the condensin I complex in mitotic chromosome segregation. Negatively regulates the condensin I-like dosage compensation complex, which functions in the regulation of X chromosome-linked gene transcription, by limiting the association of the complex with the X chromosomes. | 0.434 |
evl-14 | ZK430.5 | H38K22.1.1 | ZK430.5.1 | Uncharacterized protein. | Peptidase C50 domain-containing protein. | 0.477 |
evl-14 | him-1 | H38K22.1.1 | F28B3.7a.1 | Uncharacterized protein. | Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair (By similarity). Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). | 0.961 |
evl-14 | pqn-85 | H38K22.1.1 | Y43H11AL.3a.1 | Uncharacterized protein. | Nipped-B-like protein pqn-85; Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). | 0.970 |
evl-14 | scc-1 | H38K22.1.1 | F10G7.4.1 | Uncharacterized protein. | Sister chromatid cohesion protein 1; Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). | 0.941 |
evl-14 | scc-3 | H38K22.1.1 | F18E2.3.1 | Uncharacterized protein. | Cohesin subunit scc-3; Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Has a role in stabilization of homologous chromosome associations during meiotic syn [...] | 0.994 |
evl-14 | sep-1 | H38K22.1.1 | Y47G6A.12.2 | Uncharacterized protein. | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] | 0.477 |
evl-14 | smc-3 | H38K22.1.1 | Y47D3A.26b.1 | Uncharacterized protein. | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] | 0.992 |
evl-14 | smc-5 | H38K22.1.1 | C27A2.1.1 | Uncharacterized protein. | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | 0.856 |
evl-14 | smcl-1 | H38K22.1.1 | C44C10.4.1 | Uncharacterized protein. | Structural maintenance of chromosomes-like protein 1; Acts as a modulator of condensin function, possibly by binding to the condensin SMC subunits and thereby inhibiting their function. Negatively regulates the condensin I complex in mitotic chromosome segregation. Negatively regulates the condensin I-like dosage compensation complex, which functions in the regulation of X chromosome-linked gene transcription, by limiting the association of the complex with the X chromosomes. | 0.885 |
him-1 | ZK430.5 | F28B3.7a.1 | ZK430.5.1 | Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair (By similarity). Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). | Peptidase C50 domain-containing protein. | 0.423 |
him-1 | evl-14 | F28B3.7a.1 | H38K22.1.1 | Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair (By similarity). Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). | Uncharacterized protein. | 0.961 |