STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ncs-2Neuronal calcium sensor 2; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner; Belongs to the recoverin family. (190 aa)    
Predicted Functional Partners:
pifk-1
PhosphoInositide Four Kinase (PI-4 Kinase); Belongs to the PI3/PI4-kinase family.
    
 
 0.848
cal-2
CALmodulin related genes.
   
 0.836
dlg-1
Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family.
   
 0.834
drn-1
GTP-binding protein drn-1; Displays low GTPase activity and exists predominantly in the GTP-bound form (By similarity). Together with epac-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.
   
 
 0.763
D2007.2
Uncharacterized protein D2007.2.
      
 0.755
dmsr-2
G_PROTEIN_RECEP_F1_2 domain-containing protein.
    
 
 0.727
npr-29
Probable G-protein coupled receptor npr-29; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.707
lgc-4
Ligand-gated ion channel 4; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.701
pxd-1
PleXin Domain containing.
      
 0.700
lin-2
Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.
   
 
 0.698
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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