STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ercc-1ERCC (DNA excision repair protein) homolog. (262 aa)    
Predicted Functional Partners:
xpf-1
ERCC4 domain-containing protein.
   
 0.999
mus-81
ERCC4 domain-containing protein.
   
 
 0.997
xpa-1
XPA_C domain-containing protein.
   
 0.995
slx-1
Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...]
   
 
 0.987
msh-2
DNA_MISMATCH_REPAIR_2 domain-containing protein.
   
 0.964
him-18
High Incidence of Males (Increased X chromosome loss).
   
 
 0.964
msh-6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
 0.961
xpc-1
XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog.
   
 
 0.957
exo-1
EXOnuclease.
   
 
 0.951
lig-4
LIGase.
   
 
 0.943
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.