STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
scrm-4Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (260 aa)    
Predicted Functional Partners:
K10B3.5
Uncharacterized protein.
      
 0.810
T10H10.2
Sulfhydryl oxidase.
      
 0.758
nhr-61
Nuclear hormone receptor family member nhr-61; Orphan nuclear receptor.
  
 
 
 0.726
srsx-34
Serpentine Receptor, class SX.
      
 0.660
nceh-1
Neutral Cholesterol Ester Hydrolase homolog.
      
 0.619
mans-3
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
      
 0.610
ced-8
Cell death abnormality protein 8; Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses. Belongs to the XK family.
      
 0.599
tsen-54
tRNA_int_end_N2 domain-containing protein.
      
 0.549
kin-14
Tyrosine-protein kinase.
      
 0.548
clec-47
C-type lectin domain-containing protein.
      
 0.532
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.