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unc-54 protein (Caenorhabditis elegans) - STRING interaction network
"unc-54" - Myosin-4 in Caenorhabditis elegans
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
unc-54Myosin-4; Required for muscle contraction (1963 aa)    
Predicted Functional Partners:
unc-15
Paramyosin; Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord; Belongs to the paramyosin family (872 aa)
     
0.999
myo-3
Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1969 aa)
     
0.989
lev-11
Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F- actin (284 aa)
     
  0.988
let-2
Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development (1759 aa)
     
   
  0.986
mlc-3
Myosin, essential light chain; Protein MLC-3, isoform a (153 aa)
     
  0.985
mlc-1
Myosin regulatory light chain 1; Protein MLC-1 (mlc-1) mRNA, complete cds (170 aa)
     
  0.979
unc-22
Twitchin; Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces. Plays a role in the organization of sarcomeres in body wall muscles (7158 aa)
     
  0.979
atn-1
AcTiniN; Protein ATN-1, isoform a (920 aa)
     
  0.978
mlc-2
Myosin regulatory light chain 2; Protein MLC-2 (mlc-2) mRNA, complete cds (170 aa)
     
  0.975
unc-45
UNC-45; Protein UNC-45 (unc-45) mRNA, complete cds (961 aa)
     
 
  0.964
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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