node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cogc-1 | cogc-3 | Y54E10A.2.1 | Y71F9AM.4a.1 | Conserved Oligomeric Golgi (COG) Component. | Conserved Oligomeric Golgi (COG) Component. | 0.999 |
cogc-1 | let-2 | Y54E10A.2.1 | F01G12.5b.1 | Conserved Oligomeric Golgi (COG) Component. | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | 0.459 |
cogc-1 | mig-17 | Y54E10A.2.1 | F57B7.4.1 | Conserved Oligomeric Golgi (COG) Component. | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] | 0.699 |
cogc-1 | mig-18 | Y54E10A.2.1 | F11F1.6.1 | Conserved Oligomeric Golgi (COG) Component. | Abnormal cell migration protein 18; Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane. | 0.691 |
cogc-1 | mig-22 | Y54E10A.2.1 | PAR2.4a.3 | Conserved Oligomeric Golgi (COG) Component. | Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...] | 0.702 |
cogc-1 | mig-23 | Y54E10A.2.1 | R07E4.4.1 | Conserved Oligomeric Golgi (COG) Component. | Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis. | 0.746 |
cogc-1 | mig-6 | Y54E10A.2.1 | C37C3.6b.1 | Conserved Oligomeric Golgi (COG) Component. | Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. | 0.463 |
cogc-3 | cogc-1 | Y71F9AM.4a.1 | Y54E10A.2.1 | Conserved Oligomeric Golgi (COG) Component. | Conserved Oligomeric Golgi (COG) Component. | 0.999 |
cogc-3 | mig-17 | Y71F9AM.4a.1 | F57B7.4.1 | Conserved Oligomeric Golgi (COG) Component. | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] | 0.692 |
cogc-3 | mig-18 | Y71F9AM.4a.1 | F11F1.6.1 | Conserved Oligomeric Golgi (COG) Component. | Abnormal cell migration protein 18; Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane. | 0.692 |
cogc-3 | mig-22 | Y71F9AM.4a.1 | PAR2.4a.3 | Conserved Oligomeric Golgi (COG) Component. | Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...] | 0.703 |
cogc-3 | mig-23 | Y71F9AM.4a.1 | R07E4.4.1 | Conserved Oligomeric Golgi (COG) Component. | Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis. | 0.784 |
fbl-1 | let-2 | F56H11.1g.1 | F01G12.5b.1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | 0.832 |
fbl-1 | mig-17 | F56H11.1g.1 | F57B7.4.1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] | 0.894 |
fbl-1 | mig-18 | F56H11.1g.1 | F11F1.6.1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. | Abnormal cell migration protein 18; Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane. | 0.832 |
fbl-1 | mig-22 | F56H11.1g.1 | PAR2.4a.3 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. | Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...] | 0.461 |
fbl-1 | mig-6 | F56H11.1g.1 | C37C3.6b.1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. | Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. | 0.814 |
let-2 | cogc-1 | F01G12.5b.1 | Y54E10A.2.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Conserved Oligomeric Golgi (COG) Component. | 0.459 |
let-2 | fbl-1 | F01G12.5b.1 | F56H11.1g.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes. [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family. | 0.832 |
let-2 | mig-17 | F01G12.5b.1 | F57B7.4.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] | 0.765 |