node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y17G7B.10 | Y77E11A.2 | Y17G7B.10b.3 | Y77E11A.2.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Uncharacterized protein. | 0.920 |
Y17G7B.10 | ndx-9 | Y17G7B.10b.3 | F13H10.2a.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.916 |
Y17G7B.10 | nmat-1 | Y17G7B.10b.3 | W06B3.1.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Nicotinamide-nucleotide adenylyltransferase. | 0.919 |
Y17G7B.10 | nmat-2 | Y17G7B.10b.3 | F26H9.4.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate. Belongs to the eukaryotic NMN adenylyltransferase family. | 0.919 |
Y17G7B.10 | qns-1 | Y17G7B.10b.3 | C24F3.4a.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.929 |
Y17G7B.10 | sir-2.1 | Y17G7B.10b.3 | R11A8.4a.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | 0.900 |
Y17G7B.10 | sir-2.2 | Y17G7B.10b.3 | F46G10.7c.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacylase sir-2.2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance. | 0.900 |
Y17G7B.10 | sir-2.3 | Y17G7B.10b.3 | F46G10.3.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacylase sir-2.3; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance. Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2. Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked ; Belongs to the sirtuin family. Clas [...] | 0.900 |
Y17G7B.10 | sir-2.4 | Y17G7B.10b.3 | C06A5.11a.1 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacetylase sir-2.4; NAD-dependent protein deacetylase. | 0.901 |
Y77E11A.2 | Y17G7B.10 | Y77E11A.2.1 | Y17G7B.10b.3 | Uncharacterized protein. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | 0.920 |
Y77E11A.2 | ndx-9 | Y77E11A.2.1 | F13H10.2a.1 | Uncharacterized protein. | NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.916 |
Y77E11A.2 | nmat-1 | Y77E11A.2.1 | W06B3.1.1 | Uncharacterized protein. | Nicotinamide-nucleotide adenylyltransferase. | 0.919 |
Y77E11A.2 | nmat-2 | Y77E11A.2.1 | F26H9.4.1 | Uncharacterized protein. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate. Belongs to the eukaryotic NMN adenylyltransferase family. | 0.919 |
Y77E11A.2 | qns-1 | Y77E11A.2.1 | C24F3.4a.1 | Uncharacterized protein. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.927 |
Y77E11A.2 | sir-2.1 | Y77E11A.2.1 | R11A8.4a.1 | Uncharacterized protein. | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | 0.900 |
Y77E11A.2 | sir-2.2 | Y77E11A.2.1 | F46G10.7c.1 | Uncharacterized protein. | NAD-dependent protein deacylase sir-2.2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance. | 0.900 |
Y77E11A.2 | sir-2.3 | Y77E11A.2.1 | F46G10.3.1 | Uncharacterized protein. | NAD-dependent protein deacylase sir-2.3; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance. Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2. Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked ; Belongs to the sirtuin family. Clas [...] | 0.900 |
Y77E11A.2 | sir-2.4 | Y77E11A.2.1 | C06A5.11a.1 | Uncharacterized protein. | NAD-dependent protein deacetylase sir-2.4; NAD-dependent protein deacetylase. | 0.900 |
ndx-9 | Y17G7B.10 | F13H10.2a.1 | Y17G7B.10b.3 | NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | 0.916 |
ndx-9 | Y77E11A.2 | F13H10.2a.1 | Y77E11A.2.1 | NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. | Uncharacterized protein. | 0.916 |