STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vab-3Homeobox domain-containing protein. (455 aa)    
Predicted Functional Partners:
C47G2.3
Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
    
 
 0.907
ceh-32
Homeobox protein ceh-32; Plays a role in head morphogenesis, expression is regulated by vab-3.
   
 
 0.902
eya-1
Eyes absent homolog 1; Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister ce [...]
   
 
 0.876
tin-9.1
Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable). Belongs to the small Tim family.
   
 
 0.849
lin-32
Protein lin-32; Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs. Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis.
   
  
 0.760
mab-21
Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. Belongs to the mab-21 family.
   
  
 0.756
tin-10
Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable).
   
 
 0.737
ina-1
Integrin alpha ina-1; Plays a role in cell migration, axon fasciculation, and morphogenesis. During gonad morphogenesis, involved in distal tip cells (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p. Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis. Belongs to the integrin alpha chain family.
   
  
 0.724
egl-5
Homeobox protein egl-5; Essential for the determination of specific neurons.
   
 
 0.719
hlh-17
BHLH domain-containing protein.
   
  
 0.708
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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