STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ntr-2Nematocin receptor 2; Not directly activated by nematocin. May modulate activity of the nematocin receptor ntr- 1, leading to reduced intracellular cAMP production. Plays a role in male mating behavior. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (398 aa)    
Predicted Functional Partners:
ntc-1
Nematocin; Ligand for the G-protein coupled receptor ntr-1. Plays a role in gustatory associative learning. Also plays a role in male mating behavior.
      
 0.892
gsa-1
G protein, Subunit Alpha.
    
 
 0.776
H09F14.1
G_PROTEIN_RECEP_F1_2 domain-containing protein.
  
   
 0.722
T11F9.1
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.700
F13H6.5
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
  
 0.662
frpr-8
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.661
F40A3.7
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.660
ser-5
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
  
 0.648
tbh-1
Tyramine beta-hydroxylase; Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity. Belongs to the copper type II ascorbate-dependent monooxygenase family.
      
 0.645
npr-14
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
  
  
 0.631
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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