STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tre-4Trehalase. (635 aa)    
Predicted Functional Partners:
gob-1
Trehalose-phosphatase; Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate.
   
  
 0.904
tps-1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1; Catalyzes the production of trehalose from glucose-6- phosphate and UDP-alpha-D-glucose in a 2 step process; In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.
  
 
 0.852
hxk-1
Phosphotransferase; Belongs to the hexokinase family.
   
 
 0.845
tps-2
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2; Catalyzes the production of trehalose from glucose-6- phosphate and UDP-alpha-D-glucose in a 2 step process; In the N-terminal section; belongs to the glycosyltransferase 20 family.
  
 
 0.845
F21D5.1
Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.
   
  
 0.775
pygl-1
Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
  
 0.768
lea-1
Plant Late Embryo Abundant (LEA) related.
   
  
 0.696
R05F9.6
Uncharacterized protein; Belongs to the phosphohexose mutase family.
  
  
 0.655
nth-1
Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.
      
 0.633
ctl-2
Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis.
   
  
 0.519
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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