STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
btf-1BTAF (TBP-associated factor) homolog. (1649 aa)    
Predicted Functional Partners:
tbp-1
TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
   
 
 0.994
drap-1
CBFD_NFYB_HMF domain-containing protein.
   
 
 0.949
tlf-1
TBP-Like Factor.
   
 
 0.920
dro-1
CBFD_NFYB_HMF domain-containing protein.
    
 
 0.892
athp-1
AT Hook plus PHD finger transcription factor.
   
 
 0.794
taf-2
Transcription initiation factor TFIID subunit 2; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Belongs to the TAF2 family.
   
  
 0.782
ttb-1
Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
   
 
 0.682
tag-342
Uncharacterized protein.
   
 
 0.651
pqn-85
Nipped-B-like protein pqn-85; Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).
   
  
 0.649
isw-1
Chromatin-remodeling complex ATPase chain isw-1; Energy-transducing component of a NURF-like (nucleosome- remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
  
 
0.624
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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