STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
set-9Histone-lysine N-methyltransferase set-9; Histone methyltransferase (By similarity). Might play a role in transcriptional regulation. Together with set-26, negatively regulates lifespan in a germline-independent, partially daf- 16-dependent fashion. Together with set-26, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline ; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1623 aa)    
Predicted Functional Partners:
utx-1
UTX (Ubiquitously transcribed TPR on X) homolog.
   
 
 0.848
set-15
SET domain-containing protein.
    
 
 0.841
set-2
Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...]
   
 
 0.770
set-32
SET domain-containing protein.
   
 
 0.729
jmjd-2
Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion.
   
  
 0.720
set-25
Histone-lysine N-methyltransferase set-25; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription- induced replication stress through methylation of H3K9.
   
 
 0.713
ash-2
Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...]
   
 
 0.707
cec-3
Chromo domain-containing protein cec-3; Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc- 4 is expressed in the vulval but not in the non-vulval VC neurons.
   
 
 0.698
spr-5
Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...]
   
 
 0.672
Y24D9B.1
RNase_Zc3h12a domain-containing protein.
      
 0.666
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.