STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mec-10Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (724 aa)    
Predicted Functional Partners:
mec-6
Mechanosensory abnormality protein 6; Probable touch-cell sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Interacts with degenerin channel proteins and stabilizes the channel. Non-voltage- gated amiloride-sensitive cation channel permeable for sodium, potassium, lithium and N-methylglucamine. Belongs to the paraoxonase family.
    
 
 0.998
mec-2
Mechanosensory protein 2; Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons.
   
 
 0.997
mec-4
Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.
  
0.994
degt-1
DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
 
 0.964
mec-9
Uncharacterized protein.
   
  
 0.954
mec-5
MEC-5.
   
  
 0.940
sto-5
PHB domain-containing protein.
   
 
 0.922
sto-6
PHB domain-containing protein.
   
 
 0.922
trp-4
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.901
mec-7
Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity).
   
  
 0.884
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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