node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F17C8.9 | adss-1 | F17C8.9.1 | C37H5.6a.1 | Uncharacterized protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | 0.800 |
F17C8.9 | asns-1 | F17C8.9.1 | F25G6.6.1 | Uncharacterized protein. | Glutamine amidotransferase type-2 domain-containing protein. | 0.800 |
F17C8.9 | asns-2 | F17C8.9.1 | M02D8.4a.1 | Uncharacterized protein. | Glutamine amidotransferase type-2 domain-containing protein. | 0.802 |
F17C8.9 | got-1.2 | F17C8.9.1 | T01C8.5.1 | Uncharacterized protein. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system. | 0.837 |
F17C8.9 | got-2.1 | F17C8.9.1 | C44E4.3.1 | Uncharacterized protein. | Aspartate aminotransferase. | 0.833 |
F17C8.9 | got-2.2 | F17C8.9.1 | C14F11.1a.2 | Uncharacterized protein. | Aspartate aminotransferase. | 0.833 |
F17C8.9 | pdr-1 | F17C8.9.1 | K08E3.7a.2 | Uncharacterized protein. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.404 |
F17C8.9 | pyr-1 | F17C8.9.1 | D2085.1.1 | Uncharacterized protein. | Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP- sugars required for heparan sulfate proteoglycan biosynthesis. Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles ; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. | 0.800 |
F17C8.9 | strm-1 | F17C8.9.1 | H14E04.1.1 | Uncharacterized protein. | Sterol 4-C-methyltransferase strm-1; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of cholesterol and other sterols. May irreversibly shunt sterols away from dafachronic acid production. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 0.402 |
adss-1 | F17C8.9 | C37H5.6a.1 | F17C8.9.1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Uncharacterized protein. | 0.800 |
adss-1 | asns-1 | C37H5.6a.1 | F25G6.6.1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Glutamine amidotransferase type-2 domain-containing protein. | 0.942 |
adss-1 | asns-2 | C37H5.6a.1 | M02D8.4a.1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Glutamine amidotransferase type-2 domain-containing protein. | 0.942 |
adss-1 | got-1.2 | C37H5.6a.1 | T01C8.5.1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system. | 0.937 |
adss-1 | got-2.1 | C37H5.6a.1 | C44E4.3.1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Aspartate aminotransferase. | 0.936 |
adss-1 | got-2.2 | C37H5.6a.1 | C14F11.1a.2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Aspartate aminotransferase. | 0.951 |
adss-1 | pyr-1 | C37H5.6a.1 | D2085.1.1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP- sugars required for heparan sulfate proteoglycan biosynthesis. Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles ; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. | 0.985 |
asns-1 | F17C8.9 | F25G6.6.1 | F17C8.9.1 | Glutamine amidotransferase type-2 domain-containing protein. | Uncharacterized protein. | 0.800 |
asns-1 | adss-1 | F25G6.6.1 | C37H5.6a.1 | Glutamine amidotransferase type-2 domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | 0.942 |
asns-1 | asns-2 | F25G6.6.1 | M02D8.4a.1 | Glutamine amidotransferase type-2 domain-containing protein. | Glutamine amidotransferase type-2 domain-containing protein. | 0.909 |
asns-1 | got-1.2 | F25G6.6.1 | T01C8.5.1 | Glutamine amidotransferase type-2 domain-containing protein. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system. | 0.950 |