STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
snx-17Sorting nexin-17 homolog; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (540 aa)    
Predicted Functional Partners:
snx-3
PX domain-containing protein.
    
 
 0.928
vps-29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
    
 
 0.903
snx-6
PX domain-containing protein.
    
 
 0.896
snx-1
PX domain-containing protein.
   
 
 0.885
vps-26
Vacuolar protein sorting-associated protein 26; May play a role in vesicular protein sorting, similar to the yeast retromer proteins.
   
 
 0.879
kri-1
KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog.
    
   0.845
vps-35
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
    
 
 0.835
snx-13
Sorting NeXin.
      
 0.797
snx-14
PXA domain-containing protein.
      
 0.727
Y45F10D.10
Integrin Cytoplasmic domain-Associated Protein homolog.
      
 0.710
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.