Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dpy-13 | ergo-1 | F30B5.1.1 | R09A1.1a.1 | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | 0.533 |
| dpy-13 | eri-1 | F30B5.1.1 | T07A9.5b.1 | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | 0.582 |
| dpy-13 | lir-1 | F30B5.1.1 | F18A1.3b.1 | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. | LIR-1A protein. | 0.693 |
| ergo-1 | dpy-13 | R09A1.1a.1 | F30B5.1.1 | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. | 0.533 |
| ergo-1 | eri-1 | R09A1.1a.1 | T07A9.5b.1 | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | 0.833 |
| ergo-1 | henn-1 | R09A1.1a.1 | C02F5.6b.1 | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] | 0.868 |
| ergo-1 | lir-1 | R09A1.1a.1 | F18A1.3b.1 | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | LIR-1A protein. | 0.675 |
| ergo-1 | nrde-3 | R09A1.1a.1 | R04A9.2.1 | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation. | 0.670 |
| eri-1 | dpy-13 | T07A9.5b.1 | F30B5.1.1 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape. | 0.582 |
| eri-1 | ergo-1 | T07A9.5b.1 | R09A1.1a.1 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | 0.833 |
| eri-1 | lin-15A | T07A9.5b.1 | ZK678.1.2 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | Protein lin-15A; Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56. | 0.669 |
| eri-1 | lin-15B | T07A9.5b.1 | ZK662.4.2 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | Protein lin-15B; Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity. | 0.912 |
| eri-1 | lir-1 | T07A9.5b.1 | F18A1.3b.1 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | LIR-1A protein. | 0.707 |
| eri-1 | nrde-2 | T07A9.5b.1 | T01E8.5.1 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs- mediated silencing in nuclei. Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription. Required for exogenous RNAi-induced H3K27 methylation. Belongs to the NRDE2 family. | 0.589 |
| eri-1 | nrde-3 | T07A9.5b.1 | R04A9.2.1 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation. | 0.821 |
| henn-1 | ergo-1 | C02F5.6b.1 | R09A1.1a.1 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] | 0.868 |
| henn-1 | lir-1 | C02F5.6b.1 | F18A1.3b.1 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] | LIR-1A protein. | 0.684 |
| henn-1 | nrde-3 | C02F5.6b.1 | R04A9.2.1 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] | Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation. | 0.644 |
| hmg-1.2 | lir-1 | F47D12.4a.1 | F18A1.3b.1 | High mobility group protein 1.2. | LIR-1A protein. | 0.604 |
| lin-15A | eri-1 | ZK678.1.2 | T07A9.5b.1 | Protein lin-15A; Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56. | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. | 0.669 |
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