STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
gpa-12Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. (355 aa)    
Predicted Functional Partners:
rhgf-1
RHo Guanine nucleotide exchange Factor.
   
 0.991
gpb-1
Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces.
   
 0.936
gpb-2
Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
   
 0.936
ser-7
G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.
   
 0.933
gpa-9
Guanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
  
 
 0.918
gpa-17
G Protein, Alpha subunit.
  
 
 0.914
rho-1
Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...]
    
 0.879
mth-1
GPS domain-containing protein.
   
 
 0.869
rack-1
Guanine nucleotide-binding protein subunit beta-2-like 1; Required for the expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.
   
 
 0.839
tpa-1
Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp- 29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir- 1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in phary [...]
   
 
 0.838
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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