STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sea-1T-box transcription factor 18; Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate. (376 aa)    
Predicted Functional Partners:
ceh-39
Homeobox protein ceh-39; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family.
   
  
 0.893
sea-2
C2H2-type domain-containing protein.
      
 0.881
sex-1
Steroid hormone receptor family member cnr14; Belongs to the nuclear hormone receptor family. NR1 subfamily.
   
  
 0.863
asd-1
RRM domain-containing protein.
   
  
 0.861
xol-1
XO lethal protein 1; Acts as a primary sex-determining factor that promotes sexual differentiation. Absolutely required for proper sexual differentiation and male viability. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear; Belongs to the GHMP kinase family. Xol-1 subfamily.
   
  
 0.859
fox-1
Sex determination protein fox-1; A member of the sex determination pathway involved in making the distinction between one and two X-chromosomes. RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. Promotes binding of sup-12 to target RNA.
   
  
 0.811
pzf-1
Paired Zinc Finger protein.
   
  
 0.769
C49F5.3
Uncharacterized protein.
   
  
 0.758
tbx-34
Putative T-box protein 34.
  
   
 0.756
C17H11.2
Uncharacterized protein.
   
 
 0.713
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]