STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tbc-1TBC (Tre-2/Bub2/Cdc16) domain family. (641 aa)    
Predicted Functional Partners:
tbc-12
Rab-GAP TBC domain-containing protein.
      
 0.845
tbc-13
Rab-GAP TBC domain-containing protein.
      
 0.774
tbc-8
Rab-GAP TBC domain-containing protein.
      
 0.758
T14B1.1
Uncharacterized protein.
      
 0.695
tub-2
WD_REPEATS_REGION domain-containing protein; Belongs to the TUB family.
      
 0.692
tbc-18
TBC (Tre-2/Bub2/Cdc16) domain family.
      
 0.684
rab-19
RAB family.
   
  
 0.668
F20D1.3
Uncharacterized protein.
 
 
    0.610
F33H2.2
Uncharacterized protein.
   
  
 0.564
emb-27
Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...]
   
  
 0.559
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.