STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F20D1.3Uncharacterized protein. (463 aa)    
Predicted Functional Partners:
smo-1
Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...]
   
 
 0.803
T04A8.8
Rad60-SLD domain-containing protein.
   
 
 0.803
Y94H6A.10
Uncharacterized protein.
      
 0.695
ran-2
Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.
    
 
 0.684
imb-1
Importin N-terminal domain-containing protein.
   
 
 0.677
Y41C4A.11
LITAF domain-containing protein.
   
  
 0.661
npp-15
Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family.
   
 
 0.639
tbc-1
TBC (Tre-2/Bub2/Cdc16) domain family.
 
 
    0.610
imb-3
Importin N-terminal domain-containing protein.
   
 
 0.582
K10G6.4
Uncharacterized protein.
   
 
 0.582
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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