STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srp-7SERPIN domain-containing protein; Belongs to the serpin family. (373 aa)    
Predicted Functional Partners:
Y41C4A.11
LITAF domain-containing protein.
   
 
 0.677
clec-65
C-type LECtin.
   
  
 0.668
asp-6
Aspartic protease 6; Aspartic protease; Belongs to the peptidase A1 family.
   
 
 0.664
pals-26
Protein containing ALS2cr12 (ALS2CR12) signature.
      
 0.660
arx-4
Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
 
 
    0.636
F15D4.5
Uncharacterized protein.
      
 0.575
snap-1
SNAP (Soluble NSF Attachment Protein) homolog.
   
 
  0.545
ile-1
L-type lectin-like domain-containing protein.
   
 0.543
sel-9
Suppressor/enhancer of lin-12 protein 9; May have a role in the negative regulation of lin-12 and glp- 1 transport to the cell surface. May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles. Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction. Belongs to the EMP24/GP25L family.
   
 
  0.540
rnh-1.3
RNase H domain-containing protein.
     
 0.537
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.