STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdh-2Probable malate dehydrogenase, mitochondrial. (341 aa)    
Predicted Functional Partners:
icl-1
Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family.
  
 0.999
cts-1
Probable citrate synthase, mitochondrial.
  
 0.998
fum-1
Probable fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.997
got-2.2
Aspartate aminotransferase.
   
 0.995
got-2.1
Aspartate aminotransferase.
   
 0.993
mdh-1
Malate dehydrogenase.
   
 0.989
pyc-1
Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.986
men-1
Malic enzyme.
  
 0.985
pck-2
Phosphoenolypyruvate CarboxyKinase.
  
 
 0.982
acly-2
ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
  
 0.981
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.