STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prde-1piRNA biogenesis factor prde-1; Nuclear factor required for the production of piwi- interacting RNA (piRNA) precursors. Specifically required for piRNAs produced from loci associated with the Ruby motif. Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters. Required for normal fertility. (526 aa)    
Predicted Functional Partners:
tofu-4
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
 
 0.988
tofu-5
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
 
 0.973
snpc-4
snRNA-activating protein complex subunit 4 homolog; Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes. Required for expression of mature 21U-RNAs.
   
 
 0.967
tofu-7
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
 
 0.861
ulp-5
ULP_PROTEASE domain-containing protein.
   
 
 0.826
tofu-2
B30.2/SPRY domain-containing protein.
   
 
 0.820
tofu-1
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
  
 0.817
snpc-1.3
SNAPc (Small Nuclear RNA Activating Complex) homolog.
   
  
 0.814
tofu-6
Embryonic developmental protein tofu-6; Required maternally for early embryonic cell divisions. May have a role in DNA replication.
   
  
 0.813
parn-1
3'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro.
   
  
 0.812
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.