STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
twk-1TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (451 aa)    
Predicted Functional Partners:
twk-46
Two pore potassium channel protein sup-9.
  
  
0.820
spr-2
Suppressor of presenilin-2; Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1. Belongs to the nucleosome assembly protein (NAP) family.
      
 0.663
twk-4
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  
  
0.585
sup-9
Two pore potassium channel protein sup-9; Potassium channel involved in coordination of muscle contraction. Activity is regulated by sup-18 ; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
0.584
twk-7
TWiK family of potassium channels protein 7.
  
 
0.573
twk-5
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
 
0.569
twk-40
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  
  
 
0.559
twk-20
Two pore potassium channel protein sup-9.
  
 
0.554
twk-37
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  
  
 
0.546
twk-14
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
 0.544
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.