node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C47G2.3 | npax-1 | C47G2.3.1 | F21D12.5.1 | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | Paired domain-containing protein. | 0.614 |
C47G2.3 | tin-9.1 | C47G2.3.1 | C06G3.11.1 | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable). Belongs to the small Tim family. | 0.979 |
alr-1 | npax-1 | R08B4.2.1 | F21D12.5.1 | Homeobox domain-containing protein. | Paired domain-containing protein. | 0.729 |
alr-1 | unc-86 | R08B4.2.1 | C30A5.7b.1 | Homeobox domain-containing protein. | Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] | 0.713 |
ceh-43 | npax-1 | C28A5.4b.1 | F21D12.5.1 | Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. | Paired domain-containing protein. | 0.752 |
ceh-43 | sox-3 | C28A5.4b.1 | F40E10.2.1 | Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. | HMG box domain-containing protein. | 0.441 |
ceh-43 | unc-39 | C28A5.4b.1 | F56A12.1.1 | Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. | Homeobox protein unc-39; Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance. | 0.586 |
ceh-43 | unc-86 | C28A5.4b.1 | C30A5.7b.1 | Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. | Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] | 0.722 |
nhr-103 | npax-1 | F44C8.4.1 | F21D12.5.1 | Nuclear hormone receptor family member nhr-103; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. | Paired domain-containing protein. | 0.514 |
nhr-103 | unc-39 | F44C8.4.1 | F56A12.1.1 | Nuclear hormone receptor family member nhr-103; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. | Homeobox protein unc-39; Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance. | 0.444 |
npax-1 | C47G2.3 | F21D12.5.1 | C47G2.3.1 | Paired domain-containing protein. | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | 0.614 |
npax-1 | alr-1 | F21D12.5.1 | R08B4.2.1 | Paired domain-containing protein. | Homeobox domain-containing protein. | 0.729 |
npax-1 | ceh-43 | F21D12.5.1 | C28A5.4b.1 | Paired domain-containing protein. | Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. | 0.752 |
npax-1 | nhr-103 | F21D12.5.1 | F44C8.4.1 | Paired domain-containing protein. | Nuclear hormone receptor family member nhr-103; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. | 0.514 |
npax-1 | sox-3 | F21D12.5.1 | F40E10.2.1 | Paired domain-containing protein. | HMG box domain-containing protein. | 0.792 |
npax-1 | tin-9.1 | F21D12.5.1 | C06G3.11.1 | Paired domain-containing protein. | Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable). Belongs to the small Tim family. | 0.604 |
npax-1 | ttx-1 | F21D12.5.1 | Y113G7A.6a.1 | Paired domain-containing protein. | Homeobox domain-containing protein. | 0.544 |
npax-1 | unc-39 | F21D12.5.1 | F56A12.1.1 | Paired domain-containing protein. | Homeobox protein unc-39; Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance. | 0.580 |
npax-1 | unc-4 | F21D12.5.1 | F26C11.2.1 | Paired domain-containing protein. | Homeobox protein unc-4; Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth. Belongs to the paired homeobox family. Unc-4 subfamily. | 0.526 |
npax-1 | unc-86 | F21D12.5.1 | C30A5.7b.1 | Paired domain-containing protein. | Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] | 0.546 |