node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ceh-22 | hlh-6 | F29F11.5d.1 | T15H9.3.1 | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | 0.712 |
ceh-22 | nfya-2 | F29F11.5d.1 | Y53H1A.5a.1 | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | Nuclear transcription Factor Y, A (Alpha) subunit. | 0.488 |
ceh-22 | pha-4 | F29F11.5d.1 | F38A6.1a.1 | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] | 0.862 |
ceh-22 | tbx-2 | F29F11.5d.1 | F21H11.3.1 | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage. | 0.702 |
ceh-22 | unc-120 | F29F11.5d.1 | D1081.2.1 | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | MADS-box domain-containing protein. | 0.421 |
dbl-1 | hlh-6 | T25F10.2.1 | T15H9.3.1 | TGF_BETA_2 domain-containing protein. | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | 0.456 |
dbl-1 | tbx-2 | T25F10.2.1 | F21H11.3.1 | TGF_BETA_2 domain-containing protein. | T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage. | 0.669 |
fezf-1 | tbx-2 | Y38H8A.5.1 | F21H11.3.1 | FEZ Family zinc finger protein. | T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage. | 0.547 |
hlh-6 | ceh-22 | T15H9.3.1 | F29F11.5d.1 | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | 0.712 |
hlh-6 | dbl-1 | T15H9.3.1 | T25F10.2.1 | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | TGF_BETA_2 domain-containing protein. | 0.456 |
hlh-6 | pha-4 | T15H9.3.1 | F38A6.1a.1 | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] | 0.742 |
hlh-6 | tbx-2 | T15H9.3.1 | F21H11.3.1 | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage. | 0.680 |
hlh-6 | unc-120 | T15H9.3.1 | D1081.2.1 | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | MADS-box domain-containing protein. | 0.402 |
nfya-2 | ceh-22 | Y53H1A.5a.1 | F29F11.5d.1 | Nuclear transcription Factor Y, A (Alpha) subunit. | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | 0.488 |
nfya-2 | nfyb-1 | Y53H1A.5a.1 | W10D9.4a.1 | Nuclear transcription Factor Y, A (Alpha) subunit. | CBFD_NFYB_HMF domain-containing protein. | 0.994 |
nfya-2 | tbx-2 | Y53H1A.5a.1 | F21H11.3.1 | Nuclear transcription Factor Y, A (Alpha) subunit. | T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage. | 0.616 |
nfyb-1 | nfya-2 | W10D9.4a.1 | Y53H1A.5a.1 | CBFD_NFYB_HMF domain-containing protein. | Nuclear transcription Factor Y, A (Alpha) subunit. | 0.994 |
nfyb-1 | tbx-2 | W10D9.4a.1 | F21H11.3.1 | CBFD_NFYB_HMF domain-containing protein. | T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage. | 0.741 |
pha-4 | ceh-22 | F38A6.1a.1 | F29F11.5d.1 | Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] | Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. | 0.862 |
pha-4 | hlh-6 | F38A6.1a.1 | T15H9.3.1 | Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] | Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity. | 0.742 |