STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F22B3.8Tyrosine-protein kinase. (497 aa)    
Predicted Functional Partners:
sms-1
Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide.
      
 0.805
acr-7
Acetylcholine receptor subunit alpha-type acr-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
      
 0.698
C27D6.11
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
 0.669
ins-22
Probable insulin-like peptide alpha-type 2.
      
 0.662
W02B12.12
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
 0.657
tag-344
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
 0.615
Y106G6A.1
Protein kinase domain-containing protein.
  
 
 
 0.551
T05C12.1
Protein kinase domain-containing protein.
  
   0.545
T07F12.4
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
   0.540
R02C2.1
Protein kinase domain-containing protein.
  
 
 
 0.525
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.