STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F22B5.10Calcium load-activated calcium channel homolog; Calcium-selective channel required to prevent calcium stores from overfilling. (186 aa)    
Predicted Functional Partners:
ccdc-47
CCDC (Human Coiled Coil Domain Containing) homolog.
   
 
 0.937
nra-2
Nicalin; Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER. Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR. Regulates L- AChR sensitivity to agonists such as nicotine and levamisole at neuro- muscular junctions. In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel ; Belongs to the [...]
   
 
 0.905
fars-3
Phenylalanine--tRNA ligase beta subunit.
 
 
    0.889
sec-61
Plug_translocon domain-containing protein.
   
 
 0.809
Y38F2AR.9
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
   
   0.798
emc-3
ER membrane protein complex subunit 3.
   
 
 0.789
emo-1
Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family.
   
 
 0.782
ZK418.5
Uncharacterized protein.
   
 
 0.762
lin-37
Uncharacterized protein.
   
 
 0.761
rpl-29
60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family.
   
   0.757
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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