Probable ribosome biogenesis protein CELE_F52C12.2; Probable pre-rRNA processing protein involved in ribosome biogenesis.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.

Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.

Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan.

Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.

Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.

Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.

Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development.

Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.

Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan.

Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.

Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Probable ribosome biogenesis protein CELE_F52C12.2; Probable pre-rRNA processing protein involved in ribosome biogenesis.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

High Incidence of Males (Increased X chromosome loss).

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Abnormal cell migration protein 21; Required for determination of left/right asymmetry in nervous system. Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts. Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts. Involved in left- side QL posterior migration. In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.

C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]

Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development.