node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F13H10.3 | T04C4.1 | F13H10.3b.1 | T04C4.1a.1 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | Uncharacterized protein. | 0.865 |
F13H10.3 | flcn-1 | F13H10.3b.1 | F22D3.2a.1 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | UDENN FLCN/SMCR8-type domain-containing protein. | 0.795 |
F13H10.3 | lmtr-2 | F13H10.3b.1 | Y97E10AR.7.2 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. | 0.997 |
F13H10.3 | lmtr-3 | F13H10.3b.1 | C06H2.6a.1 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. | 0.996 |
F13H10.3 | raga-1 | F13H10.3b.1 | T24F1.1.1 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | RAs-related GTP-binding protein A. | 0.946 |
F13H10.3 | ragc-1 | F13H10.3b.1 | Y24F12A.2a.1 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | RAs-related GTP binding protein C homolog. | 0.938 |
T04C4.1 | F13H10.3 | T04C4.1a.1 | F13H10.3b.1 | Uncharacterized protein. | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | 0.865 |
T04C4.1 | flcn-1 | T04C4.1a.1 | F22D3.2a.1 | Uncharacterized protein. | UDENN FLCN/SMCR8-type domain-containing protein. | 0.999 |
T04C4.1 | lmtr-2 | T04C4.1a.1 | Y97E10AR.7.2 | Uncharacterized protein. | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. | 0.684 |
T04C4.1 | lmtr-3 | T04C4.1a.1 | C06H2.6a.1 | Uncharacterized protein. | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. | 0.778 |
T04C4.1 | lst-4 | T04C4.1a.1 | Y37A1B.2b.1 | Uncharacterized protein. | Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family. | 0.621 |
T04C4.1 | nprl-2 | T04C4.1a.1 | F49E8.1b.1 | Uncharacterized protein. | Nitrogen Permease Regulator Like homolog. | 0.785 |
T04C4.1 | nprl-3 | T04C4.1a.1 | F35H10.7a.2 | Uncharacterized protein. | GATOR complex protein NPRL3; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. | 0.789 |
T04C4.1 | raga-1 | T04C4.1a.1 | T24F1.1.1 | Uncharacterized protein. | RAs-related GTP-binding protein A. | 0.967 |
T04C4.1 | ragc-1 | T04C4.1a.1 | Y24F12A.2a.1 | Uncharacterized protein. | RAs-related GTP binding protein C homolog. | 0.973 |
flcn-1 | F13H10.3 | F22D3.2a.1 | F13H10.3b.1 | UDENN FLCN/SMCR8-type domain-containing protein. | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. | 0.795 |
flcn-1 | T04C4.1 | F22D3.2a.1 | T04C4.1a.1 | UDENN FLCN/SMCR8-type domain-containing protein. | Uncharacterized protein. | 0.999 |
flcn-1 | lmtr-2 | F22D3.2a.1 | Y97E10AR.7.2 | UDENN FLCN/SMCR8-type domain-containing protein. | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. | 0.784 |
flcn-1 | lmtr-3 | F22D3.2a.1 | C06H2.6a.1 | UDENN FLCN/SMCR8-type domain-containing protein. | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. | 0.789 |
flcn-1 | lst-4 | F22D3.2a.1 | Y37A1B.2b.1 | UDENN FLCN/SMCR8-type domain-containing protein. | Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family. | 0.803 |