STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hil-3Histone H1.3; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (208 aa)    
Predicted Functional Partners:
hil-7
HIstone H1 Like.
   
  
 0.788
his-71
Histone H3.3 type 1; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central [...]
   
 
 0.763
his-24
Histone 24; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
  
 
0.756
his-8
Histone H2B 2.
   
 
 0.722
ugt-51
UDP-GlucuronosylTransferase.
      
 0.660
ugt-14
UDP-GlucuronosylTransferase.
      
 0.660
hil-2
Histone H1.2; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
  
 
0.637
cyp-34A2
CYtochrome P450 family; Belongs to the cytochrome P450 family.
      
 0.616
htz-1
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...]
   
 
 0.599
ugt-41
UDP-GlucuronosylTransferase.
      
 0.581
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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