STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F22G12.5DHR-2 domain-containing protein; Belongs to the DOCK family. (2338 aa)    
Predicted Functional Partners:
glct-5
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.
      
 0.906
tag-52
Putative protein tag-52.
   
  
 0.827
vars-1
Valyl Amino-acyl tRNA Synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
  
 0.808
gadr-5
Y71A12B.17.
      
 0.807
tag-77
Uncharacterized protein.
   
 
 0.775
cdc-42
Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...]
   
 0.746
ced-10
Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...]
   
 0.745
ephx-1
EPHeXin (Eph-interacting GEF) homolog.
      
 0.726
agef-1
SEC7 domain-containing protein.
   
  
 0.705
cgef-1
DH domain-containing protein.
   
  
 0.696
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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