STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F23H12.5Uncharacterized protein. (802 aa)    
Predicted Functional Partners:
col-101
Col_cuticle_N domain-containing protein.
      
 0.807
adt-3
Peptidase M12B domain-containing protein.
      
 0.740
lon-3
Cuticle collagen lon-3; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape.
   
  
 0.725
exl-1
Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family.
      
 0.694
Y73E7A.8
Uncharacterized protein.
   
  
0.693
emb-9
Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons.
   
  
 0.675
manf-1
Mesencephalic astrocyte-derived neurotrophic factor homolog; Inhibits endoplasmic reticulum (ER) stress response (By similarity). Retained in the ER under normal conditions and is up- regulated and secreted by the ER in response to ER stress and hypoxia (By similarity). Following secretion by the ER, directly binds to 3-O- sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions (By similarity). Has a neuroprotecti [...]
      
 0.669
spon-1
SPONdin (Extracellular matrix glycoprotein) family.
   
  
 0.667
mig-23
Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis.
   
  
 0.661
H03E18.1
Uncharacterized protein.
   
    0.615
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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