node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0303.3 | C05C10.3 | B0303.3.2 | C05C10.3.1 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.967 |
B0303.3 | T02G5.7 | B0303.3.2 | T02G5.7.1 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.934 |
B0303.3 | Y48B6A.13 | B0303.3.2 | Y48B6A.13b.2 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.530 |
B0303.3 | Y71G12B.10 | B0303.3.2 | Y71G12B.10.1 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | Pyruvate carboxyltransferase domain-containing protein. | 0.957 |
B0303.3 | acaa-2 | B0303.3.2 | F53A2.7.2 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family. | 0.969 |
B0303.3 | ech-5 | B0303.3.2 | F56B3.5.1 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.789 |
B0303.3 | hmgr-1 | B0303.3.2 | F08F8.2.1 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.404 |
B0303.3 | hmgs-1 | B0303.3.2 | F25B4.6.1 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.998 |
B0303.3 | kat-1 | B0303.3.2 | T02G5.8.2 | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. | 0.926 |
C05C10.3 | B0303.3 | C05C10.3.1 | B0303.3.2 | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.967 |
C05C10.3 | T02G5.7 | C05C10.3.1 | T02G5.7.1 | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.985 |
C05C10.3 | Y71G12B.10 | C05C10.3.1 | Y71G12B.10.1 | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Pyruvate carboxyltransferase domain-containing protein. | 0.981 |
C05C10.3 | acaa-2 | C05C10.3.1 | F53A2.7.2 | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | ACetyl-CoA Acyltransferase 2 homolog; Belongs to the thiolase-like superfamily. Thiolase family. | 0.970 |
C05C10.3 | ech-5 | C05C10.3.1 | F56B3.5.1 | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.593 |
C05C10.3 | hmgs-1 | C05C10.3.1 | F25B4.6.1 | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.956 |
C05C10.3 | kat-1 | C05C10.3.1 | T02G5.8.2 | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family. | 0.988 |
T02G5.7 | B0303.3 | T02G5.7.1 | B0303.3.2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.934 |
T02G5.7 | C05C10.3 | T02G5.7.1 | C05C10.3.1 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.985 |
T02G5.7 | Y48B6A.13 | T02G5.7.1 | Y48B6A.13b.2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 0.725 |
T02G5.7 | Y71G12B.10 | T02G5.7.1 | Y71G12B.10.1 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. | Pyruvate carboxyltransferase domain-containing protein. | 0.968 |