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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
degt-1DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (852 aa)    
Predicted Functional Partners:
mec-10
Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.
   
 
 0.964
del-1
Degenerin del-1; Probable sodium channel subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
 
 0.908
unc-8
Degenerin unc-8.
   
 
 0.887
mec-4
Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.
   
 
 0.883
asic-1
Degenerin-like protein asic-1; Proton-gated cation channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions (By similarity).
   
 
 0.881
deg-1
Degenerin deg-1; Probable sodium channel subunit. Required by a subset of neurons.
     
 0.876
unc-105
Degenerin-like protein unc-105; Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
 
 0.816
trp-4
ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.812
egas-4
EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
 
 0.791
del-8
DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
     
 0.787
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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