STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clsp-1CLaSPin homolog. (752 aa)    
Predicted Functional Partners:
tim-1
Protein timeless homolog; Plays an important role in chromosome cohesion during both mitosis and meiosis. In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and sister chromatid cohesion. It regulates cohesin subunits to promote meiotic chromosome cohesion and localizes non-SMC (structural maintenance of chromosome) cohesin subunits to chromatin prior to or during pre-meiotic S phase. Implicated in influencin [...]
   
 
 0.989
tipn-1
Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. Belongs to the CSM3 family.
   
 
 0.984
chk-1
Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae. Essential for embryogene [...]
   
 
 0.946
psf-3
Sld5 domain-containing protein.
   
 
 0.937
ctf-4
Mcl1_mid domain-containing protein.
   
 
 0.935
K02C4.3
Probable ubiquitin carboxyl-terminal hydrolase K02C4.3.
   
 0.931
mcm-2
DNA helicase; Belongs to the MCM family.
   
 
 0.920
mus-101
Uncharacterized protein.
   
  
 0.914
hpr-9
Cell cycle checkpoint protein hpr-9; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.
   
 
 0.907
W04A8.1
Uncharacterized protein.
   
 
 0.891
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (22%) [HD]