Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ajm-1 | dlg-1 | C25A11.4f.1 | C25F6.2a.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | 0.992 |
| ajm-1 | eat-20 | C25A11.4f.1 | H30A04.1b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Abnormal pharyngeal pumping eat-20; Regulates pharyngeal pumping during feeding. | 0.602 |
| ajm-1 | erm-1 | C25A11.4f.1 | C01G8.5b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | FERM domain-containing protein. | 0.810 |
| ajm-1 | hmp-1 | C25A11.4f.1 | R13H4.4b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family. | 0.813 |
| ajm-1 | ifb-2 | C25A11.4f.1 | F10C1.7e.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. | 0.690 |
| ajm-1 | let-413 | C25A11.4f.1 | F26D11.11b.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] | 0.866 |
| ajm-1 | lin-2 | C25A11.4f.1 | F17E5.1a.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions. | 0.448 |
| ajm-1 | magu-2 | C25A11.4f.1 | C01B7.4a.2 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | MAGUK family; Belongs to the MAGUK family. | 0.571 |
| ajm-1 | par-6 | C25A11.4f.1 | T26E3.3a.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Partitioning defective protein 6; Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. Required for localizing/ maintaining par-3 at the cell periphery. Regulates mes-1 expression and/or localization pattern during early embryogenesis. Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca. Plays a role in endosome and Golgi body positioning. Belongs to the PAR6 family. | 0.660 |
| ajm-1 | pkc-3 | C25A11.4f.1 | F09E5.1.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. | 0.723 |
| dlg-1 | ajm-1 | C25F6.2a.1 | C25A11.4f.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | 0.992 |
| dlg-1 | erm-1 | C25F6.2a.1 | C01G8.5b.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | FERM domain-containing protein. | 0.843 |
| dlg-1 | hmp-1 | C25F6.2a.1 | R13H4.4b.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family. | 0.910 |
| dlg-1 | ifb-2 | C25F6.2a.1 | F10C1.7e.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. | 0.743 |
| dlg-1 | let-413 | C25F6.2a.1 | F26D11.11b.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...] | 0.940 |
| dlg-1 | lin-2 | C25F6.2a.1 | F17E5.1a.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions. | 0.904 |
| dlg-1 | magu-2 | C25F6.2a.1 | C01B7.4a.2 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | MAGUK family; Belongs to the MAGUK family. | 0.590 |
| dlg-1 | par-6 | C25F6.2a.1 | T26E3.3a.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Partitioning defective protein 6; Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. Required for localizing/ maintaining par-3 at the cell periphery. Regulates mes-1 expression and/or localization pattern during early embryogenesis. Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca. Plays a role in endosome and Golgi body positioning. Belongs to the PAR6 family. | 0.838 |
| dlg-1 | pkc-3 | C25F6.2a.1 | F09E5.1.1 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family. | Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. | 0.510 |
| eat-20 | ajm-1 | H30A04.1b.1 | C25A11.4f.1 | Abnormal pharyngeal pumping eat-20; Regulates pharyngeal pumping during feeding. | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | 0.602 |
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